Baixe no formato docx, pdf, txt ou leia online no scribd. Over a million stunning new images at your fingertips. Efek samping yang kedua dari asetol atau aspirin, dan sering menimpa anakanak, adalah terjadinya sindrom reye, yaitu suatu penyakit mematikan yang mengganggu fungsi otak dan hati. Questa pagina e stata modificata per lultima volta il 4 lug 2019 alle 10. The syndrome was first described in 1937 as an experimental neurobehavioral syndrome in monkeys with bitemporal brain lesions 1. Reyes syndrome is a rare but serious disease that causes swelling in the liver and brain. Jumlah kromosom 45 dan kehilangan satu kromosom seks pada kromosom nomor ciriciri penderita turner syndrome pasien dengan sindrom turner perempuan, tapi tidak berkembang ovumnya disgenesis ovaricular. The syndrome is characterized by complex behaviors, including.
Although it can happen at any age, it is most often seen in children. Stop wasting time in meetings and be more productive at work. Reye syndrome is an acute metabolic encephalopathy, largely affecting children and adolescents. Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. Death occurs in 2040% of those affected and about a third of those who survive are left with a significant degree of brain damage. Kelainan bisa menyebabkan penderitanya mengalami kelainan fisik seperti kelainan jantung bawaan, otototot. Recognition of this relationship has led to decreased use of salicylates in children and a marked decrease in the incidence of reye. Reye syndrome is a rapidly worsening brain disease. However, reye s syndrome can occur in older children and even in adults. Reye s syndrome usually appears after a flulike infection, upper respiratory infection, chicken pox, or other viral illness. The syndrome was first described in 1963 in australia by rdk reye and described a few months later in the united states by gm johnson. Ideal sources for wikipedia s health content are defined in the guideline wikipedia. Communicable disease control forms infectious diseases case report forms forms are provided for use by health professionals only note.
Sindrom reye atau reye s syndrome rs merupakan jenis penyakit kerusakan otak yang akut yang terjadi secara mendadak. Review of aspirinreyes syndrome warning statement april 2004 page 5 susdp at the 50th meeting of the dpsc in august 1988, after discussion of the issue and recommendations made by adrac and ntgc during the period 19861988. Even though liver toxicity typically occurs, jaundice usually does not. The disease typically is preceded by a viral infection with an intermediate diseasefree interval of 35 days. It affects all organs of the body but is most harmful to the brain and the livercausing an acute increase of pressure within the brain and, often, massive accumulations of fat in the liver and other organs. Review of aspirin reyes syndrome warning statement. There are 26 other cases of adultonset rs reported.
Reye syndrome is associated with viral infection and aspirin use. The condition is caused by occlusion of the hepatic veins that drain the liver. Sindrom reye adalah suatu kondisi serius yang dapat menyebabkan pembengkakan pada organ hati dan otak. Now that aspirin use has declined, about 2 children a year in the united states develop reye syndrome. Reye syndrome causes vomiting and mentalstatus changes. Sindrom reye adalah penyakit duatahap karena hampir selalu dikaitkan dengan infeksi virus sebelumnya, seperti influenza cacar, dingin, atau ayan sindroma reye adalah suatu sindroma ensefalopati yang penyebabnya tidak. Reyes syndrome information page national institute of. A 42yearold woman developed a flulike illness and died 8 days later with reye s syndrome rs. Presentations ppt, key, pdf logging in or signing up.
It may result in accumulation of fat in the liver and swelling of the brain. Reyes syndrome occurs almost exclusively in children although it has been reported to occur in adults. Buddchiari syndrome is a very rare condition, affecting one in a million adults. It presents with the classical triad of abdominal pain, ascites, and liver enlargement. Baral melaporkan sebanyak 11 dari 21 pasien pada kasus yang ditemukan tersebut diberikan aspirin sebelum onset terjadinya sindrom tersebut dan memiliki riwayat penggunaan salisilat seperti krim topikal dan shampoo. Started in 1995, this collection now contains 6760 interlinked topic pages divided into a tree of 31 specialty books and 732 chapters. Beberapa kelainan genetis pada manusia dapat menyebabkan syndrome, diantranya. Sindrom reye adalah penyakit duatahap karena hampir selalu dikaitkan dengan infeksi virus sebelumnya, seperti influenza cacar, dingin, atau ayan sindroma reye adalah suatu sindroma ensefalopati yang penyebabnya tidak diketahui, dan disertai dengan.
According to the national reye s syndrome foundation, the national reye s syndrome foundation. Symptoms include vomiting, listlessness, irritability or combativeness, confusion, delirium, delusions, convulsions, and loss of consciousness. Using salicylates generally aspirin during such illness increases the risk by as much as 35fold. Sindrom yang terbilang cukup langka ini kebanyakan menimpa anakanak dan remaja yang baru sembuh dari infeksi virus, seperti flu atau cacar air. Reye s syndrome, a deadly disease, strikes swiftly and can attack any child, teen, or adult without warning.
What is reyes syndrome national reyes syndrome foundation. Here are links to possibly useful sources of information about reye syndrome. Here we describe a case of reye syndrome diagnosed at postmortem liver biopsy of a threeyear old girl who presented with vomiting, low grade fever for three days and loss of consciousness for 18. Reporting is mandated for all diseases on the list unless otherwise indicated. The attack rate for reye syndrome approximated 30 to 60 cases per 100 000 influenza b infections, 2. Reye s syndrome rs or reye syndrome is a sudden, sometimes fatal, disease of the brain with degeneration of the liver. Reye syndrome differential diagnoses medscape reference.
Reye syndrome is a systemic disorder of mitochondrial function that occurs during or after viral infection. Its most common in kids who are recovering from a viral infection. However, the age of the mother may also be a risk factor. In reye like syndrome, because of inborn errors of metabolism, hypoglycemia, hypoketonemia, elevated ammonia, and organic aciduria are often evident. Reyes syndrome symptoms could be attributed to other conditions, and without thorough testing a patient can go undiagnosed which can lead to death. Reye syndrome pediatrics msd manual professional edition. Reyev sindrom je redka akutna in vcasih smrtna otroska bolezen, ki je posledica noric ali virusne okuzbe dihalnih poti, lahko v povezavi z jemanjem acetilsalicilne kisline. However, adults do not appear to be as vulnerable to permanent neural or liver damage. Diagnosing reye syndrome primarily depends on the clinical history of symptoms.
This gene provides instructions for making a protein needed for proper formation of many organs and tissues before birth. Sindrom reye, penggunaan aspirin, asam asetilsalisilat, viral infection. Oct 18, 2019 reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. This page was last edited on 26 november 2019, at 11.
Penyakit ini mempengaruhi semua organ tubuh, tapi yang peling berbahaya adalah serangan pada otak dan hati. Sindroma reye merupakan penyakit yang jarang dijumpai tetapi berakibat sangat. Although it mostly affects children and teens, anyone can get it. Latar belakang reye syndrome adalah penyakit yang mempengaruhi semua organ tubuh, tetapi yang paling mematikan hati dan otak. Reye syndrome pediatrics merck manuals professional edition. United kingdom reyes syndrome is a very rare but often fatal disease characterized by. Jurnal penentuan kadar aspirin dengan metode alkalimetri. Reye syndrome is an extremely rare but serious illness that can affect the brain and liver. Reyes syndrome is defined by the centers for disease control and prevention as an acute, noninflammatory encephalopathy with altered. Reye s syndrome is a deadly disease of children associated with the use of aspirin and aspirin containing medications during a viral illness, such as the common cold, chicken pox, and influenza.
Etiologi mekanisme yang tepat untuk menerangkan sindroma reye masih belum diketahui. Namun, belum ada penelitian yang membuktikan korelasi dosis aspirin dengan derajat keparahan sindrom reye. Kelainan sindrom down terjadi karena kelebihan jumlah kromosom pada kromosom nomor 21, yang seharusnya dua menjadi tiga. Acetylsalicylic acid and reyes syndrome world health organization. The biochemical explanation for reye like symptoms is a generalized disturbance in mitochondrial metabolism, eventually resulting in metabolic failure in the liver and other tissues. Down syndrome, it is estimated that the risk of having a second child with down syndrome is about one in 100.
Reye syndrome factsheet pdf share this share on facebook facebook share on twitter twitter web content viewer. Reyes syndrome is a rare disorder that causes brain and liver damage. Reye syndrome, acute neurologic disease that develops primarily in children following influenza, chicken pox, or other viral infections. Review of aspirinreyes syndrome warning statement april 2004 page 5 susdp at the 50th meeting of the dpsc in august 1988, after discussion of the issue and. Sindrom reye ini biasanya terjadi pada anak yang baru saja terinfeksi virus seperti chickenpox dan flu. The occurrence is higher with salicylate use for symptomatic relief during viral illness. National institutes of health consensus development conference statement march 24, 1981. Files are available under licenses specified on their description page. Sindrom reye adalah penyakit yang jarang terjadi dimana terjadi kerusakan otak dan hepar. Researchers believe that the zeb2 protein is involved in the. Reye s syndrome is an acute illness characterized by encephalopathy and fatty degeneration of the liver, and it occurs almost exclusively in children. Douglas reye, koji je zajedno sa svojim suradnicima dr. Its still not well understood, but studies have linked it to the use of aspirin salicylates or aspirin products during illnesses caused by viruses. Find, read and cite all the research you need on researchgate.
A detailed informative presentation on the nigh lethal reye s syndrome. May 05, 2016 an association has been shown to exist between reye s syndrome and the use of aspirin during the prodromal illness. Pdf reye syndrome is a rare but a very dangerous emergency that children. The surveillance for reyes syndrome in the us is focused on patients under 18 years of age. Sehingga pernyataan bahwa aspirin sebagai penyebab langsung dari sindrom reye belum dapat dibuktikan.
If your child has a headache, its usually best to stick to. The protein attaches binds to specific regions of dna and helps control the activity of particular genes. Reyes syndrome in children supriatmo departemen ilmu kesehatan anak fakultas kedokteran universitas sumatera utara abstract. To download a factsheet describing reye syndrome, click download on the right side of this page. The falling incidence is lauded as a public health success, informing the public about the dangers of giving aspirin to children under 12. Reye s syndrome rs is primarily a childrens disease, although it can occur at any age. The syndrome occurs mainly in children younger than 18. Reye s syndrome rs is a rare but potentially fatal disease that affects all organ of the body, with an especially devastating attack upon the liver and brain. This finding has led to a marked decrease in salicylate use in the us since the mid1980s except when specifically indicated, such as in kawasaki disease and a corresponding. It occurs most commonly in kids recovering from a viral infection.
The formation of a blood clot within the hepatic veins can lead to buddchiari syndrome. The disease was first reported by the australian pathologist r. A surveillance case definition is a set of uniform criteria used to define a disease for public health surveillance. Symptoms may include vomiting, personality changes, confusion, seizures, and loss of consciousness. This statement is more than five years old and is provided solely for historical purposes. The most common abnormal laboratory tests with reye syndrome include elevated liver enzymes, elevated ammonia levels, and low serum glucose levels. All structured data from the file and property namespaces is available under the creative commons cc0 license. Paling sering ditemukan pada anakanak, meskipun dapat terjadi pada berbagai usia. Karakterizira ga pojava masne jetre i encefalopatija ostecenje mozga u djece do 15 godina starosti sindrom je nazvan po dr. Sindrom reye pertama kali ditemukan oleh seorang berkebangsaan australia bernama r.
Reye s syndrome encephalopathy with fatty infiltration of the viscera is an acute illness of childhood that produces hepatic dysfunction and metabolic encephalopathy. Mowatwilson syndrome is caused by a mutation in the zeb2 also known as zfhx1b or sip1 gene. It is a biphasic illness, occurring mainly in childhood, which consists of an acute viral prodrome followed several days later by an acute encephalopathy associated with selective hepatic abnormality and metabolic decompensation. This is because doctors and parents no longer routinely give aspirin to children. All body organs are affected, with the liver and brain suffering most seriously. The cause of reye syndrome is unknown, but many cases seem to follow infection with influenza a or b or varicella. Early detection of reyes syndrome is crucial and could be lifesaving. The author defines and discusses reye s syndrome and the hypotheses relating to its causes and associating its incidence with that of chickenpox and influenza a and b. Sindrom reye gejala, penyebab dan mengobati alodokter. Reyeov sindrom je tesko ostecenje jetre i mozga s visokom smrtnoscu.
Reye syndrome is associated with giving children medications containing aspirin. The etiology of classical reye syndrome is unknown. Incidence of down syndrome and maternal age maternal age incidence of down syndrome 20 1 in 2000 24 1 in 0 27 1 in 1050 30 1 in 900 33 1 in 600 36 1 in 300 40 1 in 100. Apr 02, 2018 reye syndrome is characterized by acute noninflammatory encephalopathy and fatty degenerative liver failure. Windows 8 app store for windows free downloads and. The recent decline in the incidence of reye s syndrome appears to be related to the. It can affect people of any age, but it is most often seen in children and teenagers recovering from a.
Reye syndrome is a rare and potentially fatal pediatric illness defined as acute noninflammatory encephalopathy with fatty liver failure. Reye syndrome may also cause strange behavior such as staring and slurred speech seizures and comas loss of consciousness reye syndrome occurs 3 to 7 days after the beginning of an infection or illness caused by a virus, or during recovery from the infection or illness. Reye s syndrome represents an abrupt, profound failure of mitochondria, the cause of which is uncertain. Reye syndrome 1990 case definition recommend on facebook tweet share compartir note.